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GENE - TERM ANNOTATION REPORT

RGD ID: 70892
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdc5l
Name: cell division cycle 5-like
Acc ID: GO:0000974
Term: Prp19 complex
Definition: A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.
Definition Source(s): GOC:krc, PMID:16540691, PMID:19239890
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdc5lpart_ofISOCDC5L (Homo sapiens)1624291RGD PMID:20176811

PMID:20176811
Cdc5lpart_ofIEAUniProtKB:Q99459 or ensembl:ENSP000003605321600115EnsemblGO_REF:0000107

GO_REF:0000107
Cdc5lpart_ofIBAFB:FBgn0265574 or PANTHER:PTN000067719 or PomBase:SPAC644.12 or SGD:S000004826 or UniProtKB:Q57ZS5 or UniProtKB:Q994591600115GO_CentralGO_REF:0000033

GO_REF:0000033
Cdc5lpart_ofIEAInterPro:IPR0472421600115InterProGO_REF:0000002

GO_REF:0000002
Cdc5lpart_ofISSUniProtKB:Q9UMS41600115UniProtGO_REF:0000024

GO_REF:0000024
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