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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70883
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2ak1
Name: eukaryotic translation initiation factor 2 alpha kinase 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2ak1increases expressionEXP 6480464CTDbisphenol A results in increased expression of EIF2AK1 mRNAPMID:25181051
Eif2ak1decreases expressionISOEif2ak1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of EIF2AK1 mRNAPMID:33221593
Eif2ak1increases methylationISOEIF2AK1 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of EIF2AK1 genePMID:31601247
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