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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708554
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sulf1
Name: sulfatase 1
Acc ID: CHEBI:30563
Term: silicon dioxide
Definition: A silicon oxide made up of linear triatomic molecules in which a silicon atom is covalently bonded to two oxygens.
Chemical ID: MESH:D012822
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sulf1decreases expressionEXP 6480464CTDSilicon Dioxide results in decreased expression of SULF1 proteinPMID:29673857
Sulf1decreases expressionISOSULF1 (Homo sapiens)6480464CTDSilicon Dioxide results in decreased expression of SULF1 mRNA; Silicon Dioxide results in decreased expression of SULF1 proteinPMID:22300531 PMID:25351596 PMID:29673857
Sulf1increases expressionISOSULF1 (Homo sapiens)6480464CTDSilicon Dioxide analog results in increased expression of SULF1 mRNAPMID:23806026
Sulf1increases response to substanceISOSULF1 (Homo sapiens)6480464CTDSULF1 mRNA results in increased susceptibility to Silicon DioxidePMID:29673857
Sulf1multiple interactionsISOSULF1 (Homo sapiens)6480464CTD[SULF1 mRNA results in increased susceptibility to Silicon Dioxide] which results in increased expression of ACTA2 mRNA; [SULF1 mRNA results in increased susceptibility to Silicon Dioxide] which results in increased expression of BIRC3 mRNA; [SULF1 mRNA results in increased susceptibility to Silicon Dioxide] which results in increased expression of CCND1 mRNA; [SULF1 mRNA results in increased susceptibility to Silicon Dioxide] which results in increased expression of COL1A1 mRNA; [SULF1 mRNA results in increased susceptibility to Silicon Dioxide] which results in increased expression of JUN mRNA; [SULF1 mRNA results in increased susceptibility to Silicon Dioxide] which results in increased expression of SERPINE1 mRNA; [SULF1 mRNA results in increased susceptibility to Silicon Dioxide] which results in increased expression of VEGFA mRNA; SULF1 mRNA promotes the reaction [Silicon Dioxide results in increased expression of IL24 mRNA]; SULF1 mRNA promotes the reaction [Silicon Dioxide results in increased expression of MMP1 mRNA]PMID:29673857
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