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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708464
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atg3
Name: autophagy related 3
Acc ID: CHEBI:9381
Term: T-2 toxin
Definition: A trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals.
Chemical ID: MESH:D013605
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atg3increases expressionEXP 6480464CTDT-2 Toxin results in increased expression of ATG3 proteinPMID:29870751
Atg3increases expressionISOAtg3 (Mus musculus)6480464CTDT-2 Toxin results in increased expression of ATG3 mRNA; T-2 Toxin results in increased expression of ATG3 proteinPMID:32240701
Atg3multiple interactionsISOAtg3 (Mus musculus)6480464CTDATG3 protein affects the reaction [T-2 Toxin results in increased expression of TNF mRNA]; ATG3 protein inhibits the reaction [T-2 Toxin results in increased expression of IL1B mRNA]; ATG3 protein inhibits the reaction [T-2 Toxin results in increased expression of IL6 mRNA]; MIR155 mRNA inhibits the reaction [T-2 Toxin results in increased expression of ATG3 mRNA]; MIR155 mRNA inhibits the reaction [T-2 Toxin results in increased expression of ATG3 protein]PMID:32240701
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