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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708428
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1c3
Name: aldo-keto reductase family 1, member C3
Acc ID: CHEBI:16486
Term: cyclopentanone
Definition: A cyclic ketone that consists of cyclopentane bearing a single oxo substituent.
Chemical ID: MESH:C007201
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1c3increases reductionISOAKR1C3 (Homo sapiens)6480464CTDAKR1C3 protein results in increased reduction of cyclopentanonePMID:23261716
Akr1c3multiple interactionsISOAKR1C3 (Homo sapiens)6480464CTD[AKR1C3 protein co-treated with NADP] results in increased reduction of cyclopentanone; Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein co-treated with NADP] results in increased reduction of cyclopentanone]; NADP promotes the reaction [AKR1C3 protein results in increased reduction of cyclopentanone]PMID:23261716
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