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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a9
Name: cytochrome P450, family 3, subfamily a, polypeptide 9
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a9decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of CYP3A9 mRNAPMID:15102944
Cyp3a9increases expressionEXP 6480464CTDDexamethasone results in increased expression of CYP3A9 mRNAPMID:19562681 PMID:20888898
Cyp3a9multiple interactionsEXP 6480464CTD[Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of CYP3A9 mRNAPMID:22341215
Cyp3a9increases expressionISOCYP3A5 (Homo sapiens)6480464CTDDexamethasone results in increased expression of CYP3A5 mRNAPMID:10696073 PMID:12538830 PMID:19118567 PMID:20832446
Cyp3a9increases expressionISOCyp3a13 (Mus musculus)6480464CTDDexamethasone results in increased expression of CYP3A13 mRNAPMID:14570766 PMID:31678242
Cyp3a9multiple interactionsISOCYP3A5 (Homo sapiens)6480464CTDMifepristone inhibits the reaction [Dexamethasone results in increased expression of CYP3A5 mRNA]; NR3C1 protein affects the reaction [Dexamethasone results in increased expression of CYP3A5 mRNA]PMID:12538830
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