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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a9
Name: cytochrome P450, family 3, subfamily a, polypeptide 9
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a9increases expressionISOCYP3A5 (Homo sapiens)6480464CTDCalcitriol results in increased expression of CYP3A5 mRNAPMID:16002434 PMID:21592394 PMID:27107558
Cyp3a9multiple interactionsISOCYP3A5 (Homo sapiens)6480464CTD[Testosterone co-treated with Calcitriol] results in increased expression of CYP3A5 mRNAPMID:21592394
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