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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:34202
Term: 2,2',4,4',5,5'-hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C014024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of CYP3A4 mRNAPMID:22664347
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [NR1I2 protein results in increased expression of CYP3A4]PMID:36893891
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