Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70837
Species: Homo sapiens
RGD Object: Gene
Symbol: HGF
Name: hepatocyte growth factor
Acc ID: CHEBI:3139
Term: bleomycin A2
Definition: A bleomycin that has formula C55H84N17O21S3.
Chemical ID: MESH:D001761
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HGFdecreases expressionISOHgf (Mus musculus)6480464CTDBleomycin results in decreased expression of HGF mRNA; Bleomycin results in decreased expression of HGF proteinPMID:29408570 PMID:30825431
HGFdecreases expressionISOHgf (Rattus norvegicus)6480464CTDBleomycin results in decreased expression of HGF mRNA; Bleomycin results in decreased expression of HGF proteinPMID:16115399
HGFincreases expressionISOHgf (Mus musculus)6480464CTDBleomycin results in increased expression of HGF mRNAPMID:22687607
HGFincreases secretionISOHgf (Mus musculus)6480464CTDBleomycin results in increased secretion of HGF proteinPMID:22687607
HGFmultiple interactionsISOHgf (Mus musculus)6480464CTDBerberine inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]; Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of HGF protein]; lenabasum promotes the reaction [Bleomycin results in decreased expression of HGF protein]PMID:29408570 PMID:30825431
HGFmultiple interactionsISOHgf (Rattus norvegicus)6480464CTDvalsartan inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]; valsartan inhibits the reaction [Bleomycin results in decreased expression of HGF protein]PMID:16115399
Go Back to source page   Continue to Ontology report