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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70836
Species: Homo sapiens
RGD Object: Gene
Symbol: LPL
Name: lipoprotein lipase
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LPLaffects expressionEXP 6480464CTDbisphenol A affects the expression of LPL mRNAPMID:32175033
LPLdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of LPL mRNA; bisphenol A results in decreased expression of LPL proteinPMID:22662114 PMID:31675489 PMID:34186270
LPLdecreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of LPL genePMID:31601247
LPLincreases expressionEXP 6480464CTDbisphenol A results in increased expression of LPL mRNA; bisphenol A results in increased expression of LPL proteinPMID:23090578 PMID:25143472 PMID:29721103
LPLmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of LPL mRNA; [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of LPL protein; [bisphenol A co-treated with Fulvestrant] affects the methylation of LPL gene; [bisphenol A results in decreased expression of LPL mRNA] which affects the abundance of Triglycerides; [Vitamin D co-treated with bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] affects the expression of LPL mRNAPMID:22662114 PMID:31601247 PMID:33836827 PMID:35736896
LPLdecreases expressionISOLpl (Mus musculus)6480464CTDbisphenol A results in decreased expression of LPL mRNAPMID:27502578 PMID:30133442
LPLdecreases expressionISOLpl (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of LPL mRNAPMID:24105817 PMID:25181051 PMID:28657538 PMID:30816183 PMID:31129395 PMID:32145629 PMID:32528016 PMID:34947998
LPLincreases expressionISOLpl (Mus musculus)6480464CTDbisphenol A results in increased expression of LPL mRNAPMID:15659569 PMID:30566610 PMID:33221593 PMID:35341816 PMID:37755785
LPLincreases expressionISOLpl (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of LPL mRNAPMID:20019905 PMID:25748669 PMID:34165232
LPLmultiple interactionsISOLpl (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of LPL mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL protein]; [bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of LPL mRNA; [bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL mRNA; [bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL protein; [Dietary Sucrose co-treated with Dietary Fats co-treated with bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of LPL mRNA; bisphenol A inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA]PMID:15659569 PMID:22197818 PMID:27273607 PMID:30665118 PMID:30722647
LPLmultiple interactionsISOLpl (Rattus norvegicus)6480464CTDlithospermate B inhibits the reaction [bisphenol A results in increased expression of LPL mRNA]PMID:34165232
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