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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70836
Species: Homo sapiens
RGD Object: Gene
Symbol: LPL
Name: lipoprotein lipase
Acc ID: CHEBI:16113
Term: cholesterol
Definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.
Chemical ID: MESH:D002784
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LPLincreases expressionEXP 6480464CTDCholesterol results in increased expression of LPL mRNAPMID:26296894
LPLmultiple interactionsISOLpl (Rattus norvegicus)6480464CTD[Cholesterol co-treated with Cholic Acid] results in increased activity of LPL protein; Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of LPL protein]; Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of LPL protein]PMID:30273964
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