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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70826
Species: Mus musculus
RGD Object: Gene
Symbol: Cdk5
Name: cyclin dependent kinase 5
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk5increases activityEXP 6480464CTDEthanol results in increased activity of CDK5 proteinPMID:30143782
Cdk5multiple interactionsEXP 6480464CTD[Ethanol results in increased activity of CDK5 protein] which results in increased degradation of CDK5R1 protein; CNR1 protein affects the reaction [[Ethanol results in increased activity of CDK5 protein] which results in increased degradation of CDK5R1 protein]; CNR1 protein affects the reaction [Ethanol results in increased activity of CDK5 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [[Ethanol results in increased activity of CDK5 protein] which results in increased degradation of CDK5R1 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [Ethanol results in increased activity of CDK5 protein]; Rimonabant inhibits the reaction [[Ethanol results in increased activity of CDK5 protein] which results in increased degradation of CDK5R1 protein]; Rimonabant inhibits the reaction [Ethanol results in increased activity of CDK5 protein]PMID:30143782
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