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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70822
Species: Homo sapiens
RGD Object: Gene
Symbol: FGF2
Name: fibroblast growth factor 2
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FGF2decreases activityEXP 6480464CTDSB 203580 results in decreased activity of FGF2 proteinPMID:15249425
FGF2multiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [FGF2 protein results in increased phosphorylation of RB1 protein]; SB 203580 inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]PMID:15249425 PMID:15631803 PMID:26800359
FGF2increases secretionISOFgf2 (Rattus norvegicus)6480464CTDSB 203580 results in increased secretion of FGF2 proteinPMID:28087833
FGF2multiple interactionsISOFgf2 (Rattus norvegicus)6480464CTDSB 203580 inhibits the reaction [AGT protein modified form results in increased expression of FGF2 mRNA]; SB 203580 inhibits the reaction [AGT protein modified form results in increased expression of FGF2 protein]; SB 203580 promotes the reaction [diphenylarsinic acid results in increased secretion of FGF2 protein]PMID:21108934 PMID:28087833
FGF2multiple interactionsISOFgf2 (Mus musculus)6480464CTDSB 203580 inhibits the reaction [FGF2 protein results in increased secretion of TNFRSF11B protein]PMID:25290095
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