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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70506
Species: Homo sapiens
RGD Object: Gene
Symbol: IGF1
Name: insulin like growth factor 1
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGF1increases secretionEXP 6480464CTDperfluorooctane sulfonic acid results in increased secretion of IGF1 proteinPMID:31923581
IGF1multiple interactionsEXP 6480464CTD1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of IGF1 mRNA]; 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased secretion of IGF1 protein]; [Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of and results in increased secretion of IGF1 protein; [Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of IGF1 mRNA; ESR1 protein affects the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased secretion of IGF1 protein]PMID:31923581
IGF1multiple interactionsISOIgf1 (Mus musculus)6480464CTD[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of IGF1 mRNA; [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of IGF1 mRNAPMID:36331819
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