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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70506
Species: Homo sapiens
RGD Object: Gene
Symbol: IGF1
Name: insulin like growth factor 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGF1increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of IGF1 proteinPMID:26138014
IGF1multiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IGF1 mRNA; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IGF1 protein]PMID:26138014 PMID:35301059
IGF1multiple interactionsISOIgf1 (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IGF1 mRNA; [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of IGF1 mRNAPMID:29373603 PMID:31614173 PMID:31904401
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