GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | IGF1 | decreases expression | ISO | Igf1 (Mus musculus) | 6480464 | CTD | Paraquat results in decreased expression of IGF1 protein | PMID:34811946 | IGF1 | increases expression | ISO | Igf1 (Mus musculus) | 6480464 | CTD | Paraquat results in increased expression of IGF1 protein | PMID:23898955 | IGF1 | increases expression | ISO | Igf1 (Rattus norvegicus) | 6480464 | CTD | Paraquat results in increased expression of IGF1 mRNA | PMID:20498031 | IGF1 | multiple interactions | ISO | Igf1 (Mus musculus) | 6480464 | CTD | [Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA; IGF1 gene mutant form inhibits the reaction [Paraquat results in decreased expression of SLC8A1 protein]; IGF1 gene mutant form inhibits the reaction [Paraquat results in increased expression of ATP2A2 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA]; ST2825 inhibits the reaction [Paraquat results in decreased expression of IGF1 protein] | PMID:17979500 PMID:23963992 PMID:34811946 | |
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