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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70506
Species: Homo sapiens
RGD Object: Gene
Symbol: IGF1
Name: insulin like growth factor 1
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGF1affects expressionISOIgf1 (Rattus norvegicus)6480464CTDCaffeine affects the expression of IGF1 proteinPMID:29343424
IGF1decreases activityISOIgf1 (Rattus norvegicus)6480464CTDCaffeine results in decreased activity of IGF1 proteinPMID:24239806
IGF1decreases expressionISOIgf1 (Rattus norvegicus)6480464CTDCaffeine results in decreased expression of IGF1 mRNA; Caffeine results in decreased expression of IGF1 proteinPMID:22583948 PMID:29343424 PMID:29966748 PMID:30528684
IGF1decreases secretionISOIgf1 (Mus musculus)6480464CTDCaffeine results in decreased secretion of IGF1 proteinPMID:1995187
IGF1multiple interactionsISOIgf1 (Mus musculus)6480464CTD[Caffeine co-treated with bisphenol A] results in decreased expression of IGF1 mRNAPMID:31756439
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