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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70503
Species: Mus musculus
RGD Object: Gene
Symbol: Tfrc
Name: transferrin receptor
Acc ID: CHEBI:50385
Term: hemin
Definition: It is used as a prescription medication to relieve repeated attacks of acute intermittent porphyria related to the menstrual cycle in affected women.
Chemical ID: MESH:D006427
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tfrcdecreases expressionISOTfrc (Rattus norvegicus)6480464CTDHemin results in decreased expression of TFRC proteinPMID:16568477
Tfrcdecreases expressionISOTFRC (Homo sapiens)6480464CTDHemin results in decreased expression of TFRC mRNA; Hemin results in decreased expression of TFRC proteinPMID:16760464 PMID:21414390 PMID:25576684
Tfrcmultiple interactionsISOTFRC (Homo sapiens)6480464CTD[Hemin results in decreased abundance of Iron] which results in increased expression of TFRC mRNA; hydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA]; hydroxyhydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA]; Phenol promotes the reaction [Hemin results in decreased expression of TFRC mRNA]PMID:12393473 PMID:21414390
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