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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70501
Species: Mus musculus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk2decreases activityISOCdk2 (Rattus norvegicus)6480464CTDSimvastatin results in decreased activity of CDK2 proteinPMID:18804536
Cdk2decreases expressionISOCDK2 (Homo sapiens)6480464CTDSimvastatin results in decreased expression of CDK2 proteinPMID:20878096
Cdk2decreases expressionISOCdk2 (Rattus norvegicus)6480464CTDSimvastatin results in decreased expression of CDK2 proteinPMID:10412745 PMID:26577051
Cdk2multiple interactionsISOCDK2 (Homo sapiens)6480464CTD[Simvastatin results in decreased degradation of CDKN1A protein] which results in decreased activity of CDK2 protein; [Simvastatin results in decreased degradation of CDKN1B protein] which results in decreased activity of CDK2 proteinPMID:17928568
Cdk2multiple interactionsISOCdk2 (Rattus norvegicus)6480464CTDgeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CDK2 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CDK2 protein]PMID:26577051
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