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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70501
Species: Mus musculus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk2affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of CDK2 mRNAPMID:21570461
Cdk2decreases activityEXP 6480464CTDTetrachlorodibenzodioxin results in decreased activity of CDK2 proteinPMID:16636136
Cdk2decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CDK2 mRNAPMID:21041162
Cdk2increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CDK2 proteinPMID:10398686
Cdk2multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNA2 protein binds to CDKN1A protein]]] which results in decreased activity of CDK2 protein; [Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNA2 protein binds to CDKN1B protein]]] which results in decreased activity of CDK2 protein; [Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1A protein]]] which results in decreased activity of CDK2 protein; [Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1B protein]]] which results in decreased activity of CDK2 protein; Tetrachlorodibenzodioxin inhibits the reaction [CCNE1 protein binds to CDK2 protein]; Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNA2 protein binds to CDKN1A protein]]; Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNA2 protein binds to CDKN1B protein]]; Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNA2 protein]]; Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1A protein]]; Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1B protein]]; Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein]]PMID:16636136 PMID:20637255
Cdk2decreases expressionISOCDK2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CDK2 mRNAPMID:21802500
Cdk2decreases expressionISOCdk2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CDK2 mRNAPMID:20724799 PMID:21215274 PMID:33387578
Cdk2increases expressionISOCDK2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of CDK2 mRNAPMID:21296121
Cdk2multiple interactionsISOCDK2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased activity of CDK2 protein]; Tetrachlorodibenzodioxin promotes the reaction [Estradiol inhibits the reaction [CDK2 protein binds to CDKN1A protein]]PMID:9705214
Cdk2multiple interactionsISOCdk2 (Rattus norvegicus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in decreased expression of CDK2 mRNA; Tetrachlorodibenzodioxin promotes the reaction [CCNA2 protein binds to CDK2 protein]; Tetrachlorodibenzodioxin results in increased activity of [CCNA2 protein binds to CDK2 protein]PMID:12387751 PMID:17141280 PMID:20724799
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