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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70499
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Birc5
Name: baculoviral IAP repeat-containing 5
Acc ID: CHEBI:63632
Term: topotecan
Definition: A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Chemical ID: MESH:D019772
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Birc5decreases expressionEXP 6480464CTDTopotecan results in decreased expression of BIRC5 mRNAPMID:25729387
Birc5multiple interactionsEXP 6480464CTD[oxaliplatin co-treated with Topotecan] results in decreased expression of BIRC5 mRNAPMID:25729387
Birc5increases degradationISOBirc5 (Mus musculus)6480464CTDTopotecan results in increased degradation of BIRC5 proteinPMID:19812371
Birc5multiple interactionsISOBirc5 (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Topotecan results in increased degradation of BIRC5 protein]; TRP53 inhibits the reaction [Topotecan results in increased degradation of BIRC5 protein]PMID:19812371
Birc5multiple interactionsISOBIRC5 (Homo sapiens)6480464CTD[Topotecan co-treated with pifithrin] results in increased degradation of BIRC5 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of BIRC5 protein]PMID:19812371
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