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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70499
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Birc5
Name: baculoviral IAP repeat-containing 5
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Birc5affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of BIRC5 mRNAPMID:34747641
Birc5increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of BIRC5 mRNA; Tetrachlorodibenzodioxin results in increased expression of BIRC5 proteinPMID:19520675 PMID:25843524
Birc5affects expressionISOBirc5 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of BIRC5 mRNAPMID:21570461
Birc5decreases expressionISOBirc5 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of BIRC5 mRNAPMID:15034205
Birc5multiple interactionsISOBirc5 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BIRC5 mRNA; AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BIRC5 mRNA]PMID:15034205 PMID:17942748
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