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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70498
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb1increases expressionEXP 6480464CTDBortezomib results in increased expression of NFKB1 mRNAPMID:35121005
Nfkb1multiple interactionsEXP 6480464CTDBerberine inhibits the reaction [Bortezomib results in increased expression of NFKB1 mRNA]PMID:35121005
Nfkb1decreases expressionISONFKB1 (Homo sapiens)6480464CTDBortezomib results in decreased expression of NFKB1 mRNA; Bortezomib results in decreased expression of NFKB1 proteinPMID:17626072 PMID:25913414
Nfkb1multiple interactionsISONFKB1 (Homo sapiens)6480464CTD[Bortezomib co-treated with vorinostat] results in decreased activity of [NFKB1 protein binds to RELA protein]; [resveratrol co-treated with Bortezomib] results in decreased activity of [RELA protein binds to NFKB1 protein]; Bortezomib inhibits the reaction [belinostat results in increased expression of NFKB1 protein]; Bortezomib inhibits the reaction [romidepsin results in increased expression of NFKB1 protein]; Bortezomib promotes the reaction [Fenretinide inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]PMID:12893773 PMID:16230421 PMID:17164350 PMID:18223231
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