GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfkb1 | decreases activity | EXP | | 6480464 | CTD | Curcumin results in decreased activity of NFKB1 protein | PMID:19225048 | Nfkb1 | multiple interactions | EXP | | 6480464 | CTD | [Zinc binds to Curcumin] which affects the expression of NFKB1 mRNA; Curcumin inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]] | PMID:17887948 PMID:19589337 | Nfkb1 | decreases activity | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | Curcumin analog results in decreased activity of NFKB1 protein; Curcumin results in decreased activity of NFKB1 protein | PMID:16173963 PMID:17041101 PMID:17596214 | Nfkb1 | decreases expression | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | Curcumin results in decreased expression of NFKB1 protein | PMID:18555241 PMID:18593936 | Nfkb1 | decreases localization | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | Curcumin results in decreased localization of NFKB1 protein | PMID:16299251 | Nfkb1 | multiple interactions | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]]; Curcumin inhibits the reaction [Oxygen deficiency affects the localization of NFKB1 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased activity of NFKB1 protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Curcumin results in decreased activity of [NFKB1 protein binds to RELA protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]] | PMID:15489888 PMID:16023083 PMID:16219905 PMID:16243823 PMID:17399992 PMID:17640567 PMID:23452621 | Nfkb1 | multiple interactions | ISO | Nfkb1 (Mus musculus) | 6480464 | CTD | Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Curcumin inhibits the reaction [NFKB1 protein binds to RELA protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of NFKB1 mRNA] | PMID:18006147 PMID:18752423 PMID:21811692 PMID:34272803 | | ||||||||||||||||||||||
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