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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70498
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
Acc ID: CHEBI:351346
Term: phenethyl isothiocyanate
Definition: An isothiocyanate having a phenethyl group attached to the nitrogen. It is a naturally occurring compound found in some cruciferous vegetables (e.g. watercress) and is known to possess anticancer properties.
Chemical ID: MESH:C058305
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb1decreases expressionISONFKB1 (Homo sapiens)6480464CTDphenethyl isothiocyanate results in decreased expression of NFKB1 mRNAPMID:32070777
Nfkb1multiple interactionsISONFKB1 (Homo sapiens)6480464CTD[indole-3-carbinol co-treated with phenethyl isothiocyanate] results in decreased expression of NFKB1 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of and results in decreased activity of NFKB1 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of NFKB1 mRNA; phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB1 mRNA]; phenethyl isothiocyanate results in decreased expression of and results in decreased activity of NFKB1 proteinPMID:23724058 PMID:32070777
Nfkb1multiple interactionsISONfkb1 (Mus musculus)6480464CTDphenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB1 mRNA]PMID:20423518
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