GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfkb1 | affects localization | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide affects the localization of NFKB1 protein | PMID:25410152 | Nfkb1 | affects localization | ISO | Nfkb1 (Mus musculus) | 6480464 | CTD | Arsenic Trioxide affects the localization of NFKB1 protein | PMID:25410152 | Nfkb1 | decreases activity | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased activity of NFKB1 protein | PMID:18922898 | Nfkb1 | decreases expression | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of NFKB1 mRNA; Arsenic Trioxide results in decreased expression of NFKB1 protein | PMID:18349030 PMID:20458559 PMID:20471514 PMID:30333888 PMID:33634982 | Nfkb1 | increases expression | ISO | Nfkb1 (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in increased expression of NFKB1 mRNA | PMID:15073043 | Nfkb1 | multiple interactions | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | [BIBR 1532 co-treated with Arsenic Trioxide] affects the expression of NFKB1 mRNA; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased activity of NFKB1 protein]; Arsenic Trioxide inhibits the reaction [RELA protein binds to NFKB1 protein]; JAK1 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of NFKB1 protein]; STAT3 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of NFKB1 protein] | PMID:15314284 PMID:18922898 PMID:32645343 PMID:33634982 | |
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