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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70498
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb1affects localizationISONFKB1 (Homo sapiens)6480464CTDArsenic Trioxide affects the localization of NFKB1 proteinPMID:25410152
Nfkb1affects localizationISONfkb1 (Mus musculus)6480464CTDArsenic Trioxide affects the localization of NFKB1 proteinPMID:25410152
Nfkb1decreases activityISONFKB1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased activity of NFKB1 proteinPMID:18922898
Nfkb1decreases expressionISONFKB1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of NFKB1 mRNA; Arsenic Trioxide results in decreased expression of NFKB1 proteinPMID:18349030 PMID:20458559 PMID:20471514 PMID:30333888 PMID:33634982
Nfkb1increases expressionISONfkb1 (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of NFKB1 mRNAPMID:15073043
Nfkb1multiple interactionsISONFKB1 (Homo sapiens)6480464CTD[BIBR 1532 co-treated with Arsenic Trioxide] affects the expression of NFKB1 mRNA; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased activity of NFKB1 protein]; Arsenic Trioxide inhibits the reaction [RELA protein binds to NFKB1 protein]; JAK1 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of NFKB1 protein]; STAT3 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of NFKB1 protein]PMID:15314284 PMID:18922898 PMID:32645343 PMID:33634982
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