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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70496
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk14
Name: mitogen activated protein kinase 14
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk14affects expressionEXP 6480464CTDresveratrol affects the expression of MAPK14 mRNAPMID:15748624
Mapk14multiple interactionsEXP 6480464CTDresveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of MAPK14 mRNA]PMID:25833014
Mapk14decreases expressionISOMAPK14 (Homo sapiens)6480464CTDresveratrol results in decreased expression of MAPK14 proteinPMID:18089832
Mapk14multiple interactionsISOMAPK14 (Homo sapiens)6480464CTD[Plant Extracts co-treated with Resveratrol] results in increased expression of MAPK14 mRNAPMID:23557933
Mapk14multiple interactionsISOMapk14 (Mus musculus)6480464CTD[resveratrol co-treated with Glucose] results in decreased expression of MAPK14 mRNA; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK14 protein]PMID:16322078 PMID:24659233
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