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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70487
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin beta 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctnnb1affects localizationEXP 6480464CTDbisphenol A affects the localization of CTNNB1 proteinPMID:25381574
Ctnnb1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of CTNNB1 mRNA; bisphenol A results in decreased expression of CTNNB1 proteinPMID:19497385 PMID:25381574 PMID:25963729 PMID:27174447
Ctnnb1increases expressionEXP 6480464CTDbisphenol A results in increased expression of CTNNB1 proteinPMID:32145629
Ctnnb1multiple interactionsEXP 6480464CTD[Estradiol co-treated with bisphenol A] results in decreased expression of CTNNB1 mRNA; bisphenol A results in decreased expression of and results in increased phosphorylation of CTNNB1 protein; bisphenol A results in increased phosphorylation of and affects the localization of CTNNB1 protein; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CTNNB1 mRNA]; WNT3A protein affects the reaction [bisphenol A results in decreased expression of and results in increased phosphorylation of CTNNB1 protein]PMID:25381574 PMID:25963729 PMID:27174447
Ctnnb1affects expressionISOCTNNB1 (Homo sapiens)6480464CTDbisphenol A affects the expression of CTNNB1 mRNA; bisphenol A affects the expression of CTNNB1 proteinPMID:30903817 PMID:34186270
Ctnnb1affects localizationISOCtnnb1 (Mus musculus)6480464CTDbisphenol A affects the localization of CTNNB1 proteinPMID:26063408
Ctnnb1affects localizationISOCTNNB1 (Homo sapiens)6480464CTDbisphenol A affects the localization of CTNNB1 proteinPMID:32360864
Ctnnb1decreases expressionISOCtnnb1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of CTNNB1 mRNA; bisphenol A results in decreased expression of CTNNB1 proteinPMID:23900028 PMID:26063408 PMID:30303745 PMID:35278557 PMID:37372067
Ctnnb1decreases expressionISOCTNNB1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of CTNNB1 proteinPMID:26922907 PMID:30303745 PMID:33376534
Ctnnb1decreases methylationISOCtnnb1 (Mus musculus)6480464CTDbisphenol A results in decreased methylation of CTNNB1 promoterPMID:27312807
Ctnnb1increases expressionISOCtnnb1 (Mus musculus)6480464CTDbisphenol A results in increased expression of CTNNB1 mRNA; bisphenol A results in increased expression of CTNNB1 proteinPMID:33221593 PMID:33802611
Ctnnb1increases expressionISOCTNNB1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of CTNNB1 mRNA; bisphenol A results in increased expression of CTNNB1 proteinPMID:33024228 PMID:34602561 PMID:37567409
Ctnnb1increases phosphorylationISOCTNNB1 (Homo sapiens)6480464CTDbisphenol A results in increased phosphorylation of CTNNB1 proteinPMID:36232920
Ctnnb1multiple interactionsISOCtnnb1 (Mus musculus)6480464CTDHDAC2 protein affects the reaction [bisphenol A results in decreased expression of CTNNB1 mRNA]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of CTNNB1 protein]PMID:37372067
Ctnnb1multiple interactionsISOCTNNB1 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of CTNNB1 gene; [Phenolsulfonphthalein deficiency co-treated with bisphenol A deficiency] results in increased expression of CTNNB1 protein; bisphenol A results in decreased expression of and affects the localization of CTNNB1 protein; bisphenol A results in increased expression of and results in decreased phosphorylation of CTNNB1 protein; bisphenol A results in increased expression of and results in increased stability of CTNNB1 mRNA; CSNK1A1 protein inhibits the reaction [bisphenol A results in decreased phosphorylation of CTNNB1 protein]; Decitabine inhibits the reaction [bisphenol A results in decreased expression of CTNNB1 protein]; MIR214 mRNA inhibits the reaction [bisphenol A results in increased expression of and results in increased stability of CTNNB1 mRNA]PMID:24532171 PMID:30303745 PMID:31601247 PMID:31629898 PMID:32360864
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