GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDSimvastatin results in decreased activity of CDK2 protein

PMID:18804536
decreases expressionEXP 6480464CTDSimvastatin results in decreased expression of CDK2 protein

PMID:10412745, PMID:26577051
multiple interactionsEXP 6480464CTDgeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CDK2 protein]

Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CDK2 protein]

PMID:26577051
decreases expressionISORGD:13520106480464CTDSimvastatin results in decreased expression of CDK2 protein

PMID:20878096
multiple interactionsISORGD:13520106480464CTD[Simvastatin results in decreased degradation of CDKN1A protein] which results in decreased activity of CDK2 protein

[Simvastatin results in decreased degradation of CDKN1B protein] which results in decreased activity of CDK2 protein

PMID:17928568
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.