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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70373
Species: Homo sapiens
RGD Object: Gene
Symbol: BAX
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BAXaffects expressionEXP 6480464CTDFolic Acid affects the expression of BAX mRNAPMID:16361273
BAXmultiple interactionsEXP 6480464CTDFolic Acid affects the reaction [Homocysteine affects the expression of BAX mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of BAX protein]; Folic Acid inhibits the reaction [aluminum maltolate results in increased expression of BAX protein]; Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BAX mRNA]PMID:27113042 PMID:29250709 PMID:30581319
BAXincreases expressionISOBax (Mus musculus)6480464CTDFolic Acid results in increased expression of BAX proteinPMID:31593741 PMID:33404076 PMID:35191561
BAXmultiple interactionsISOBax (Mus musculus)6480464CTDNicorandil inhibits the reaction [Folic Acid results in increased expression of BAX protein]; nilotinib inhibits the reaction [Folic Acid results in increased expression of BAX protein]; PTHLH protein inhibits the reaction [Folic Acid results in increased expression of BAX protein]; Trimetazidine inhibits the reaction [Folic Acid results in increased expression of BAX protein]PMID:16672315 PMID:31593741 PMID:33404076 PMID:35191561
BAXmultiple interactionsISOBax (Rattus norvegicus)6480464CTD[Folic Acid co-treated with Isoflavones] results in decreased expression of BAX protein; [Vitamin E co-treated with Folic Acid] affects the expression of BAX protein; Folic Acid inhibits the reaction [Homocysteine results in increased expression of BAX mRNA]; Folic Acid inhibits the reaction [Nicotine results in increased expression of BAX protein]PMID:16933212 PMID:20060418 PMID:29972271 PMID:31721048
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