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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70373
Species: Homo sapiens
RGD Object: Gene
Symbol: BAX
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:16827
Term: corticosterone
Definition: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Chemical ID: MESH:D003345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BAXaffects expressionISOBax (Rattus norvegicus)6480464CTDCorticosterone affects the expression of BAX mRNAPMID:27988398
BAXincreases expressionISOBax (Rattus norvegicus)6480464CTDCorticosterone results in increased expression of BAX proteinPMID:29625166
BAXmultiple interactionsISOBax (Rattus norvegicus)6480464CTDEstradiol inhibits the reaction [Corticosterone results in increased expression of BAX protein]; Estradiol promotes the reaction [Testosterone inhibits the reaction [Corticosterone results in increased expression of BAX protein]]; so-ochim-tang-gamibang affects the reaction [Corticosterone affects the expression of BAX mRNA]; Testosterone inhibits the reaction [Corticosterone results in increased expression of BAX protein]; Testosterone promotes the reaction [Estradiol inhibits the reaction [Corticosterone results in increased expression of BAX protein]]PMID:27988398 PMID:29625166
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