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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69659
Species: Homo sapiens
RGD Object: Gene
Symbol: ICAM1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ICAM1multiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [Chenodeoxycholic Acid results in increased expression of ICAM1 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; SB 203580 inhibits the reaction [Particulate Matter results in increased expression of ICAM1 mRNA]; SB 203580 inhibits the reaction [TNF results in increased expression of ICAM1 protein]; SB 203580 inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 mRNA]; SB 203580 inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 protein]PMID:10792388 PMID:16582018 PMID:19020780 PMID:22226621
ICAM1multiple interactionsISOIcam1 (Rattus norvegicus)6480464CTDSB 203580 inhibits the reaction [resveratrol results in decreased expression of ICAM1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein]PMID:21192278 PMID:23285267
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