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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69659
Species: Homo sapiens
RGD Object: Gene
Symbol: ICAM1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:3429
Term: Carnosol
Definition: A diterpenoid that has formula C20H26O4.
Chemical ID: MESH:C068623
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ICAM1multiple interactionsEXP 6480464CTD[HMOX1 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein; [NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]PMID:20116392
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