Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	69659
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	ICAM1
Name:	intercellular adhesion molecule 1

Acc ID:	CHEBI:139030
Term:	hydroxysafflor yellow A
Definition:	A C-glycosyl compound that is 3,4,5-trihydroxycyclohexa-2,5-dien-1-one which is substituted by beta-D-glucosyl groups at positions 2 and 4, and by a p-hydroxycinnamoyl group at position 6. It is the main bioactive compound of a traditional Chinese medicine obtained from safflower (Carthamus tinctorius).
Chemical ID:	MESH:C085278

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
ICAM1	decreases expression	EXP		6480464	CTD	hydroxysafflor yellow A results in decreased expression of ICAM1 protein	PMID:32705535
ICAM1	multiple interactions	EXP		6480464	CTD	hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]	PMID:22007554
ICAM1	multiple interactions	ISO	Icam1 (Rattus norvegicus)	6480464	CTD	hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of ICAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of ICAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 protein]	PMID:24192212

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