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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69474
Species: Mus musculus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:207229
Term: dihydroartemisinin
Definition: A sesquiterpenoid compound which is used as a drug for treatment of malaria.
Chemical ID: MESH:C039060
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf1multiple interactionsISOSrebf1 (Rattus norvegicus)15036816RGDDihydroartemisinin inhibits the reaction [ethanol increases expression of Srebf1 mRNA and protein in liver] 
Srebf1multiple interactionsISOSREBF1 (Homo sapiens)6480464CTD[artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]; artenimol inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]; artenimol inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]PMID:27939985
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