Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69474
Species: Mus musculus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf1multiple interactionsEXP 6480464CTD1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [[Progesterone co-treated with Estradiol] results in increased expression of SREBF1 mRNA]; [Progesterone co-treated with Estradiol] results in increased expression of SREBF1 mRNAPMID:21768169
Srebf1decreases expressionISOSrebf1 (Rattus norvegicus)6480464CTDEstradiol results in decreased expression of SREBF1 mRNA; Estradiol results in decreased expression of SREBF1 proteinPMID:26164745 PMID:32145629
Srebf1decreases expressionISOSREBF1 (Homo sapiens)6480464CTDEstradiol results in decreased expression of SREBF1 mRNAPMID:31614463
Srebf1multiple interactionsISOSREBF1 (Homo sapiens)6480464CTD[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]; [Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]; Benzo(a)pyrene inhibits the reaction [Estradiol inhibits the reaction [Oleic Acid results in increased expression of SREBF1 mRNA]]; Benzo(a)pyrene inhibits the reaction [Estradiol inhibits the reaction [Oleic Acid results in increased expression of SREBF1 protein]]; Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]; Estradiol inhibits the reaction [Oleic Acid results in increased expression of SREBF1 mRNA]; Estradiol inhibits the reaction [Oleic Acid results in increased expression of SREBF1 protein]; Estradiol inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]; NR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]]; NR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]]PMID:21768169 PMID:31730885
Go Back to source page   Continue to Ontology report