GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Srebf1 | decreases expression | EXP | | 6480464 | CTD | Palmitic Acid results in decreased expression of SREBF1 mRNA | PMID:34968464 | Srebf1 | increases expression | EXP | | 6480464 | CTD | Palmitic Acid results in increased expression of SREBF1 mRNA; Palmitic Acid results in increased expression of SREBF1 protein; Palmitic Acid results in increased expression of SREBF1 protein modified form | PMID:29414781 PMID:30208301 PMID:31421115 PMID:32905826 PMID:37271273 | Srebf1 | multiple interactions | EXP | | 6480464 | CTD | [osteum co-treated with Palmitic Acid] results in increased expression of SREBF1 protein; [Palmitic Acid co-treated with Ethanol] results in increased expression of SREBF1 mRNA; [Palmitic Acid co-treated with sodium arsenite] results in decreased expression of SREBF1 mRNA; acanthoic acid inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 mRNA]; acanthoic acid inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 mRNA]; decabromobiphenyl ether promotes the reaction [[osteum co-treated with Palmitic Acid] results in increased expression of SREBF1 protein]; GW 3965 inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 mRNA]; GW 3965 inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein] | PMID:30208301 PMID:31421115 PMID:32905826 PMID:34757160 PMID:34968464 PMID:37271273 | Srebf1 | increases expression | ISO | SREBF1 (Homo sapiens) | 6480464 | CTD | Palmitic Acid results in increased expression of SREBF1 mRNA; Palmitic Acid results in increased expression of SREBF1 protein | PMID:25943029 PMID:30208301 PMID:37142143 PMID:37769864 | Srebf1 | multiple interactions | ISO | Srebf1 (Rattus norvegicus) | 6480464 | CTD | [Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in increased expression of SREBF1 protein; [Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA; quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA] | PMID:26190035 PMID:26854922 | Srebf1 | multiple interactions | ISO | SREBF1 (Homo sapiens) | 6480464 | CTD | 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]; [Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA; [Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 protein; ATG5 protein promotes the reaction [Resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]; ATG7 protein affects the reaction [trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]; BECN1 protein promotes the reaction [Resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]; Dibutyl Phthalate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA]; dorsomorphin inhibits the reaction [Huangqin-Tang inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]; Huangqin-Tang inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 mRNA]; Huangqin-Tang inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]; isosilybin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 protein]; morroniside inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]; RELA protein affects the reaction [Palmitic Acid results in increased expression of SREBF1 protein]; Resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein] | PMID:25943029 PMID:30208301 PMID:36347319 PMID:37142143 PMID:37769864 PMID:38092172 | |
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