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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69474
Species: Mus musculus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:15756
Term: hexadecanoic acid
Definition: A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Chemical ID: MESH:D019308
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf1decreases expressionEXP 6480464CTDPalmitic Acid results in decreased expression of SREBF1 mRNAPMID:34968464
Srebf1increases expressionEXP 6480464CTDPalmitic Acid results in increased expression of SREBF1 mRNA; Palmitic Acid results in increased expression of SREBF1 protein; Palmitic Acid results in increased expression of SREBF1 protein modified formPMID:29414781 PMID:30208301 PMID:31421115 PMID:32905826 PMID:37271273
Srebf1multiple interactionsEXP 6480464CTD[osteum co-treated with Palmitic Acid] results in increased expression of SREBF1 protein; [Palmitic Acid co-treated with Ethanol] results in increased expression of SREBF1 mRNA; [Palmitic Acid co-treated with sodium arsenite] results in decreased expression of SREBF1 mRNA; acanthoic acid inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 mRNA]; acanthoic acid inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 mRNA]; decabromobiphenyl ether promotes the reaction [[osteum co-treated with Palmitic Acid] results in increased expression of SREBF1 protein]; GW 3965 inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 mRNA]; GW 3965 inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]PMID:30208301 PMID:31421115 PMID:32905826 PMID:34757160 PMID:34968464 PMID:37271273
Srebf1increases expressionISOSREBF1 (Homo sapiens)6480464CTDPalmitic Acid results in increased expression of SREBF1 mRNA; Palmitic Acid results in increased expression of SREBF1 proteinPMID:25943029 PMID:30208301 PMID:37142143 PMID:37769864
Srebf1multiple interactionsISOSrebf1 (Rattus norvegicus)6480464CTD[Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in increased expression of SREBF1 protein; [Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA; quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA]PMID:26190035 PMID:26854922
Srebf1multiple interactionsISOSREBF1 (Homo sapiens)6480464CTD3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]; [Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA; [Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 protein; ATG5 protein promotes the reaction [Resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]; ATG7 protein affects the reaction [trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]; BECN1 protein promotes the reaction [Resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]; Dibutyl Phthalate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA]; dorsomorphin inhibits the reaction [Huangqin-Tang inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]; Huangqin-Tang inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 mRNA]; Huangqin-Tang inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]; isosilybin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 protein]; morroniside inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]; RELA protein affects the reaction [Palmitic Acid results in increased expression of SREBF1 protein]; Resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]PMID:25943029 PMID:30208301 PMID:36347319 PMID:37142143 PMID:37769864 PMID:38092172
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