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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:78510
Term: dorsomorphin
Definition: A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Chemical ID: MESH:C516138
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDdorsomorphin inhibits the reaction [Resveratrol metabolite inhibits the reaction [TO-901317 results in increased expression of SREBF1 mRNA]]

PMID:24633463
multiple interactionsISORGD:694736480464CTD[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SREBF1 mRNA, dorsomorphin inhibits the reaction [deoxypodophyllotoxin inhibits the reaction [TO-901317 results in increased expression of SREBF1 protein]], dorsomorphin inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]], dorsomorphin inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]], dorsomorphin inhibits the reaction [puag-haad inhibits the reaction [TO-901317 results in increased expression of SREBF1 protein]], dorsomorphin inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein]

PMID:23319015, PMID:23465592, PMID:27188386, PMID:29702089, PMID:30148990
multiple interactionsISORGD:694746480464CTDdorsomorphin inhibits the reaction [cinnamic aldehyde results in decreased expression of SREBF1 mRNA]

PMID:21401097
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.