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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of SREBF1 mRNA

PMID:28657538
increases expressionEXP 6480464CTDbisphenol A results in increased expression of SREBF1 mRNA, bisphenol A results in increased expression of SREBF1 protein

PMID:20019905, PMID:25112833, PMID:25181051, PMID:28859904, PMID:29552716
multiple interactionsEXP 6480464CTDbisphenol A inhibits the reaction [SREBF1 protein binds to CPT1A promoter], bisphenol A promotes the reaction [Dietary Fats results in increased expression of SREBF1 mRNA], bisphenol A promotes the reaction [Dietary Fats results in increased expression of SREBF1 protein], Dietary Fats promotes the reaction [bisphenol A results in increased expression of SREBF1 mRNA], Dietary Fats promotes the reaction [bisphenol A results in increased expression of SREBF1 protein]

PMID:25112833, PMID:25748669
affects expressionISORGD:694746480464CTDbisphenol A affects the expression of SREBF1 mRNA alternative form, bisphenol A affects the expression of SREBF1 protein

PMID:21932408
affects methylationISORGD:694746480464CTDbisphenol A affects the methylation of SREBF1 promoter

PMID:27334623
decreases expressionISORGD:694746480464CTDbisphenol A results in decreased expression of SREBF1 mRNA

PMID:24959901
decreases methylationISORGD:694746480464CTDbisphenol A results in decreased methylation of SREBF1 promoter

PMID:27502578, PMID:28796629
increases expressionISORGD:694736480464CTDbisphenol A results in increased expression of SREBF1 mRNA, bisphenol A results in increased expression of SREBF1 protein

PMID:25047013, PMID:25619500, PMID:27014939, PMID:28483554, PMID:29721103
increases expressionISORGD:694746480464CTDbisphenol A results in increased expression of SREBF1 mRNA, bisphenol A results in increased expression of SREBF1 protein

PMID:21932408, PMID:25111128, PMID:27145005, PMID:27502578, PMID:28483554, PMID:28500084, PMID:28796629
increases response to substanceISORGD:694746480464CTDSREBF1 mRNA results in increased susceptibility to bisphenol A

PMID:27502578
multiple interactionsISORGD:694736480464CTDMIR192 mRNA inhibits the reaction [bisphenol A results in increased expression of SREBF1 mRNA], MIR192 mRNA inhibits the reaction [bisphenol A results in increased expression of SREBF1 protein], N-piperidinyl-(8-chloro-1-(2, 4-dichlorophenyl)-1, 4, 5, 6-tetrahydrobenzo(6, 7)cyclohepta(1, 2-c)pyrazole-3-carboxamide) inhibits the reaction [bisphenol A results in increased expression of SREBF1 mRNA], SREBF1 protein affects the reaction [bisphenol A results in increased expression of FASN mRNA], SREBF1 protein affects the reaction [bisphenol A results in increased expression of PPARG mRNA]

PMID:27014939, PMID:28483554
multiple interactionsISORGD:694746480464CTD[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA], bisphenol A promotes the reaction [NFE2L2 protein binds to SREBF1 promoter], bisphenol A results in increased expression of and results in increased phosphorylation of SREBF1 protein, MIR192 mRNA inhibits the reaction [bisphenol A results in increased expression of SREBF1 mRNA], MIR192 mRNA inhibits the reaction [bisphenol A results in increased expression of SREBF1 protein], SREBF1 mRNA promotes the reaction [bisphenol A results in increased expression of FASN mRNA]

PMID:23756648, PMID:27502578, PMID:28483554, PMID:28796629
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.