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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:27902
Term: tetracycline
Definition: A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.
Chemical ID: MESH:D013752
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTetracycline results in decreased expression of SREBF1 mRNA

PMID:17202758, PMID:17522070, PMID:24469900
increases expressionISORGD:694736480464CTDTetracycline results in increased expression of SREBF1 mRNA

PMID:27089845
increases expressionISORGD:694746480464CTDTetracycline results in increased expression of SREBF1 mRNA

PMID:16917069
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.