Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDGlucose results in increased expression of SREBF1 protein

PMID:23647015
multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein], 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein], Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF1 protein], exoenzyme C3, Clostridium botulinum inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein], fatostatin inhibits the reaction [Glucose promotes the reaction [SREBF1 protein binds to TGFB1 promoter]], fatostatin inhibits the reaction [Glucose results in increased activity of and results in increased cleavage of SREBF1 protein], Glucose promotes the reaction [SREBF1 protein binds to FASN promoter], Glucose promotes the reaction [SREBF1 protein binds to TGFB1 promoter], Glucose results in increased activity of and results in increased cleavage of SREBF1 protein, L 709049 analog inhibits the reaction [Glucose results in increased expression of SREBF1 protein], PD168393 inhibits the reaction [Glucose results in increased activity of and results in increased cleavage of SREBF1 protein], Quercetin inhibits the reaction [Glucose results in increased expression of SREBF1 protein], RTKI cpd inhibits the reaction [Glucose results in increased activity of and results in increased cleavage of SREBF1 protein], SREBF1 protein affects the reaction [Glucose results in increased expression of TGFB1 mRNA], Wortmannin inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein], Y 27632 inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein]

PMID:22031849, PMID:23647015
increases expressionISORGD:694736480464CTDGlucose results in increased expression of SREBF1 mRNA, Glucose results in increased expression of SREBF1 protein

PMID:23319015, PMID:23647015
increases expressionISORGD:694746480464CTDGlucose results in increased expression of SREBF1 mRNA, Glucose results in increased expression of SREBF1 protein

PMID:10913129, PMID:15066988, PMID:23090186
multiple interactionsISORGD:694736480464CTDAllopurinol inhibits the reaction [Glucose results in increased expression of SREBF1 protein], dorsomorphin inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]], dorsomorphin inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]], L 709049 analog inhibits the reaction [Glucose results in increased expression of SREBF1 protein], Niacinamide inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]], platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA], platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein], Quercetin inhibits the reaction [Glucose results in increased expression of SREBF1 protein], STO 609 inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]]

PMID:23319015, PMID:23647015
multiple interactionsISORGD:694746480464CTDresveratrol inhibits the reaction [Glucose results in increased expression of SREBF1 protein]

PMID:23090186
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.