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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:16196
Term: oleic acid
Definition: An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.
Chemical ID: MESH:D019301
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDOleic Acid results in increased expression of SREBF1 mRNA

PMID:23395669
multiple interactionsEXP 6480464CTD[Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in increased expression of SREBF1 protein, [Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA, quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA], sophocarpine inhibits the reaction [Oleic Acid results in increased expression of SREBF1 mRNA]

PMID:23395669, PMID:26190035, PMID:26854922
decreases expressionISORGD:694736480464CTDOleic Acid results in decreased expression of SREBF1 mRNA, Oleic Acid results in decreased expression of SREBF1 protein

PMID:15949695, PMID:23603006, PMID:30611723
multiple interactionsISORGD:694736480464CTD[6-(4-chlorophenyl)imidazo(2, 1-b)(1, 3)thiazole-5-carbaldehyde O-(3, 4-dichlorobenzyl)oxime co-treated with Oleic Acid] results in decreased expression of SREBF1 mRNA, [GW 4064 co-treated with Oleic Acid] results in decreased expression of SREBF1 mRNA, [GW 7647 co-treated with Oleic Acid] results in decreased expression of SREBF1 mRNA, Plant Extracts inhibits the reaction [Oleic Acid results in decreased expression of SREBF1 mRNA], Plant Extracts inhibits the reaction [Oleic Acid results in decreased expression of SREBF1 protein]

PMID:23603006, PMID:30611723
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.