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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69408
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lcn2
Name: lipocalin 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lcn2increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of LCN2 mRNAPMID:20959002 PMID:21215274 PMID:33387578
Lcn2affects expressionISOLcn2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of LCN2 mRNAPMID:28922406
Lcn2decreases expressionISOLcn2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of LCN2 mRNAPMID:16611356
Lcn2increases expressionISOLCN2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of LCN2 mRNAPMID:19619570
Lcn2increases expressionISOLcn2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of LCN2 mRNAPMID:17949056 PMID:28213091
Lcn2multiple interactionsISOLCN2 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LCN2 mRNAPMID:19619570
Lcn2multiple interactionsISOLcn2 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LCN2 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of LCN2 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of LCN2 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of LCN2 mRNA]PMID:15667827 PMID:17942748 PMID:24052564 PMID:25975270
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