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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69401
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acsl4
Name: acyl-CoA synthetase long-chain family member 4
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acsl4affects expressionISORGD:694446480464CTDperfluorooctanoic acid affects the expression of ACSL4 mRNA

PMID:19429403
Acsl4increases expressionISORGD:694446480464CTDperfluorooctanoic acid results in increased expression of ACSL4 mRNA

PMID:17681415, PMID:18467677, PMID:20936131, PMID:30657992
Acsl4multiple interactionsISORGD:694446480464CTDPPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of ACSL4 mRNA]

PMID:18467677, PMID:20936131
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.