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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69401
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acsl4
Name: acyl-CoA synthetase long-chain family member 4
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acsl4decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of ACSL4 mRNAPMID:21215274 PMID:32109520 PMID:33387578
Acsl4increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of ACSL4 mRNAPMID:34747641
Acsl4affects expressionISOAcsl4 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of ACSL4 mRNAPMID:28922406
Acsl4decreases expressionISOACSL4 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ACSL4 mRNAPMID:26238291
Acsl4decreases expressionISOAcsl4 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ACSL4 mRNAPMID:18796159 PMID:22539624 PMID:26290441
Acsl4multiple interactionsISOAcsl4 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ACSL4 mRNAPMID:16214954
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