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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69401
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acsl4
Name: acyl-CoA synthetase long-chain family member 4
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acsl4multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Testosterone] results in increased expression of ACSL4 mRNA; [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of ACSL4 mRNA; Testosterone inhibits the reaction [Dexamethasone results in increased expression of ACSL4 mRNA]PMID:20032058 PMID:26496021 PMID:32741896
Acsl4decreases expressionISOAcsl4 (Mus musculus)6480464CTDTestosterone deficiency results in decreased expression of ACSL4 mRNAPMID:33848595
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