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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69401
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acsl4
Name: acyl-CoA synthetase long-chain family member 4
Acc ID: CHEBI:143205
Term: 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid
Definition: A perfluorinated compound that is 2-propoxypentanoic acid in which all 11 of the hydrogens attached to carbon atoms have been replaced by fluorine atoms. Used as an alternative to perfluorooctanoic acid in the fluoropolymer industry for years, its widespread environmental distribution, high bioaccumulation capability, and human exposure have caused great concern, particularly as its potential toxicity and health risk is still largely unknown.
Chemical ID: MESH:C000608800
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTD2, 3, 3, 3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid results in increased expression of ACSL4 mRNA

PMID:30920876
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.