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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69342
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Serpinb5
Name: serpin family B member 5
Acc ID: CHEBI:4708
Term: doxazosin
Definition: A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.
Chemical ID: MESH:D017292
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases response to substanceISORGD:690896480464CTDSERPINB5 protein results in increased susceptibility to Doxazosin

PMID:16007219
multiple interactionsISORGD:690896480464CTDSERPINB5 protein promotes the reaction [Doxazosin results in decreased expression of VEGFA mRNA alternative form], SERPINB5 protein promotes the reaction [Doxazosin results in decreased expression of VEGFA protein], SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of BAX protein], SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 mRNA], SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 protein]

PMID:16007219
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.