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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69342
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Serpinb5
Name: serpin family B member 5
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:690896480464CTDFluorouracil results in increased expression of SERPINB5 mRNA

PMID:17982676
increases response to substanceISORGD:690896480464CTDSERPINB5 protein results in increased susceptibility to Fluorouracil

PMID:16331619
multiple interactionsISORGD:690896480464CTD[Fluorouracil co-treated with irinotecan] results in decreased expression of SERPINB5 mRNA, TP53 protein affects the reaction [Fluorouracil results in increased expression of SERPINB5 mRNA], TP53 protein promotes the reaction [Fluorouracil results in increased expression of SERPINB5 mRNA]

PMID:15016801, PMID:16391804, PMID:17982676
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.