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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69338
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a6
Name: solute carrier family 22 member 6
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a6affects expressionEXP 6480464CTDQuercetin affects the expression of SLC22A6 proteinPMID:24958931
Slc22a6multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]PMID:19605544
Slc22a6decreases activityISOSLC22A6 (Homo sapiens)6480464CTDQuercetin results in decreased activity of SLC22A6 proteinPMID:32159797
Slc22a6multiple interactionsISOSLC22A6 (Homo sapiens)6480464CTDQuercetin inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine analog]; Quercetin inhibits the reaction [SLC22A6 protein results in increased susceptibility to N(6)-cyclopropyl-9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine]; Quercetin inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]PMID:19605544 PMID:23856525
Slc22a6multiple interactionsISOSlc22a6 (Mus musculus)6480464CTDQuercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 mRNA]; Quercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]PMID:21909718
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